Is Hyperhomocysteinemia an Important Risk Factor of Cardiovascular Disease?

Is hyperhomocysteinemia an important risk factor of cardiovascular disease?

In the last couple of decades many studies have been carried out on the association of moderately high plasma levels of total homocysteine (tHcy) with coronary artery disease, cerebrovascular disease, peripheral artery disease and venous thromboembolism. Most studies showed a positive association between tHcy and thrombosis risk. However, despite this, many investigators are still skeptical abo...

[Hyperhomocysteinemia as a risk factor for cardiovascular disease].

Cardiovascular and peripheral vascular disease are the major cause of morbidity and mortality in general population today. Hyperhomocysteinemia, a new independent risk factor for atherosclerotic vascular disease, has been described in the last ten years. Moderate hyperhomocysteinemia occurs in 5-7% of general population, and is associated in the third and fourth deceny of life with premature co...

Prospective study of hyperhomocysteinemia as an adverse cardiovascular risk factor in end-stage renal disease.

BACKGROUND Retrospective and case-control studies show that hyperhomocysteinemia is an independent risk factor for atherosclerosis in patients with end-stage renal disease. We studied prospectively the association between total homocysteine and cardiovascular outcomes. METHODS AND RESULTS In all, 167 patients (93 men, 74 women; mean age, 56.3+/-14.7 years) were followed for a mean duration of...

[Low HDL-cholesterol--an important risk factor for cardiovascular diseases].

It has been known for quite a long time that the concentration of HDL-cholesterol correlates inversely with cardiovascular disease (CVD) risk and that low HDL-cholesterol is an independent CVD risk factor. This review aims to highlight evidence on several topics concerning the role of HDL particles and the importance of HDL-cholesterol. The main antiatherogenic functions of HDL particles are pr...

Age is an Important Risk Factor for Type 2 Diabetes Mellitus and Cardiovascular Diseases